IL-8RA Polyclonal Antibody, 100ul Filtration CBL has been found to

CBL has been found to be mutated or translocated in many cancers including acute myeloid leukaemia

The protein encoded by this gene is a member of the tripartite motif (TRIM) family

a multiprotein complex that acts at the interface between core mRNP particles and RNA polymerase II (RNAPII) and integrates transcript elongation with the regulation of alternative splicing: the DBIRD complex affects local transcript elongation rates and alternative splicing of a large set of exons embedded in (A + T)-rich DNA regions

NA polymerase that promotes microhomology-mediated end-joining (MMEJ)

The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs)

IL-8RA Polyclonal Antibody, 100ul Filtration CBL has been found toThe protein encoded by this gene is a member of the G protein coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G protein activated second messenger system. Knockout studies in mice suggested that this protein inhibits embryonic oligodendrocyte precursor migration in developing spinal cord. This gene, IL8RB, a gene encoding another high affinity IL8