NFKappaB-p65 Polyclonal Antibody, 100ul[BT-AP05993] Peptide Synthesis The ADF (actin-depolymerizing factor)/cofilin family

The ADF (actin-depolymerizing factor)/cofilin family (see MIM 601442) is composed of stimulus-responsive mediators of actin dynamics

attachment

This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis

Mutations in this gene have been associated with autosomal recessive congenital fibrosis of the extraocular muscles

Also associates with MAPK14/p38-alpha

NFKappaB-p65 Polyclonal Antibody, 100ul[BT-AP05993] Peptide Synthesis The ADF (actin-depolymerizing factor)/cofilin familyNF kappa B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF kappa B moves to the nucleus and activates transcription of specific genes. NF kappa B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF kappa B is NFKB1 complexed with the product of RELA, RELA. Four