HECAM Polyclonal Antibody, 50ul Insect Expression Three alternatively spliced transcript variants

Three alternatively spliced transcript variants encoding two distinct isoforms have been reported for this gene

Alternative splicing of EXO1 results in three transcript variants encoding two different isoforms

the encoded protein (also referred to as neuroleukin) functions as a neurotrophic factor that promotes survival of skeletal motor neurons and sensory neurons

based on the arrangement of the first 2 of the 4 conserved cysteine residues

whose members are components of the multiprotein cytoplasmic dynein complex

HECAM Polyclonal Antibody, 50ul Insect Expression Three alternatively spliced transcript variantsThe protein encoded by this gene is a single pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene.