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UBE4A Polyclonal Antibody, 50ul Electronic Pipette The protein encoded by this

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UBE4A Polyclonal Antibody, 50ul Electronic Pipette The protein encoded by thisUBE4A encodes a member of the U box ubiquitin ligase family. The ubiquitination factor E4A is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants

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Description

The protein encoded by this gene belongs to the glutathione peroxidase family| members of which catalyze the reduction of hydrogen peroxide| organic hydroperoxides and lipid hydroperoxides| and thereby protect cells against oxidative damage

This pathway involves the phosphorylation of L-fucose to form beta-L-fucose-1-phosphate| and then condensation of the beta-L-fucose-1-phosphate with GTP by fucose-1-phosphate guanylyltransferase to form GDP-beta-L-fucose

E2F6 encodes a member of a family of transcription factors that play a crucial role in the control of the cell cycle

Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway| thereby allowing activation and nuclear translocation of the NFKB complex

SLC25A12 encodes a calcium-binding mitochondrial carrier protein

UBE4A Polyclonal Antibody, 50ul Electronic Pipette The protein encoded by thisUBE4A encodes a member of the U box ubiquitin ligase family. The ubiquitination factor E4A is involved in multiubiquitin chain assembly and plays a critical role in chromosome condensation and separation through the polyubiquitination of securin. Autoantibodies against the encoded protein may be markers for scleroderma and Crohn's disease. A pseudogene of this gene is located on the long arm of chromosome 3. Alternatively spliced transcript variants

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