PLC Gamma1 Polyclonal Antibody, 100ul[BT-AP07262] Stepper The encoded protein is associated

The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome

The product of this gene is a precursor polypeptide that presumably undergoes proteolytic processing to generate the final MAP1A heavy chain and LC2 light chain

Originally localized to both chromosomes 2 and 7

IQGAP1 encodes a member of the IQGAP family

The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation

PLC Gamma1 Polyclonal Antibody, 100ul[BT-AP07262] Stepper The encoded protein is associatedThe protein encoded by PLCG1 (phospholipase C gamma 1) catalyzes the formation of inositol 1,4,5 trisphosphate and diacylglycerol from phosphatidylinositol 4,5 bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of receptor mediated tyrosine kinase activators. For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RasGRP1 to translocate