PARL Monoclonal Antibody, 50ul Miscellaneous Expression of this gene is

Expression of this gene is also a marker for Reed-Sternberg cells in Hodgkin's lymphoma

The C-terminal half of this protein has been shown to bind DNA

Mutations in TSC2 lead to tuberous sclerosis complex

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and also to protein kinase C and the phosphatase calcineurin

PARL Monoclonal Antibody, 50ul Miscellaneous Expression of this gene isThis gene encodes a member of the rhomboid family of intramembrane serine proteases that is localized to the inner mitochondrial membrane. The encoded protein regulates mitochondrial remodeling and apoptosis through regulated substrate proteolysis. Proteolytic processing of the encoded protein results in the release of a small peptide, P beta, which may transit to the nucleus. Mutations in this gene may be associated with Parkinson's disease.