Rat Α2 Macroglobulin, ALPHA2-MG ELISA Kit, 96T Syringe Filter TIMP4 (TIMP metallopeptidase inhibitor 4)

TIMP4 (TIMP metallopeptidase inhibitor 4) belongs to the TIMP gene family

Mutations in this gene are associated with myeloproliferative diseases

Contains 6 LRR (leucine-rich) repeats

DPYSL2 encodes a member of the collapsin response mediator protein family

and GTP) and contain two of the three consensus motifs found in typical GTP-binding proteins

Rat Α2 Macroglobulin, ALPHA2-MG ELISA Kit, 96T Syringe Filter TIMP4 (TIMP metallopeptidase inhibitor 4)Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a Peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight