Anti-Covid-19 Spike mAb IgG(05FC), 1mg Funnels The SOCS box may act

The SOCS box may act as a bridge between specific substrate-binding domains and E3 ubiquitin protein ligases

It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form

Belongs to the LEM family

Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation

Translation of this protein is initiated at a non-AUG (AUA) start codon

Anti-Covid-19 Spike mAb IgG(05FC), 1mg Funnels The SOCS box may actCoronaviruses (CoVs) infect human and animals and cause varieties of diseases, including respiratory, enteric, renal, and neurological diseases. CoV uses its spike protein to recognize ACE2 as its receptors and mediate membrane fusion and virus entry into host cells(PMID: 32221306). Each monomer of trimeric S protein is about 180 kDa, and contains two subunits, S1 and S2,S1 recognizes and binds to host receptors, and subsequent conformational changes