AZD-2281 - CAS# 763113-22-0 308 Solubility: DMSO and water up

Solubility: DMSO and water up to 50 mM

I-BET762 could be dosed to the mice by oral administration at 10-30 mg/kg once per day

CAS Number: 1099644-42-4

12 cells (EC50 ~261 nM) and H146 ALL cells (EC50 ~4

288(15):10684-91

AZD-2281 - CAS# 763113-22-0 308 Solubility: DMSO and water upAZD 2281, also known as Olaparib or KU 59436, CAS No. 763113 22 0, is a small molecule inhibitor of the nuclear enzyme poly(ADP ribose) polymerase (PARP) with potential chemosensitizing, radiosensitizing, and antineoplastic activities. AZD 2281 selectively binds to and inhibits PARP, inhibiting PARP mediated repair of single strand DNA breaks; PARP inhibition may enhance the cytotoxicity of DNA damaging agents and may reverse tumor cell