SCH 527123 thiouracil STF-62247 shows selective toxicity and

STF-62247 shows selective toxicity and growth inhibition of renal cells lacking VHL

NCCOC1C=C(N=C(C=1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1)C(=O)NC1=CC(OCCN)=C2C=CC=CC2=N1

COC1C=C(C=C(OC)C=1OC)/C=C/CCCN1CCN(CCC1)CCC/C=C/C1=CC(OC)=C(OC)C(=C1)OC

PubMed PMID: 24778011

Molecular Weight: 212

SCH 527123 thiouracil STF-62247 shows selective toxicity andNavarixin, also known as SCH527123, PS291822 and MK 7123, is a potent CXCR2 antagonist. SCH 527123 shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models. SCH 527123 showed concentration dependent antiproliferative effects in HCT116, Caco2, and their respective IL 8 overexpressing variants colorectal cancer cell lines. CH 527123 was able to suppress CXCR2 mediated signal transduction as shown through decreased