ML792 Catalog No.:M7530-10 5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide

5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamide

The acute transcriptional response to SW044248 in sensitive HCC4017 cells correlated significantly with inhibitors of topoisomerases and SW044248 inhibited topoisomerase 1 (Top1) but not topoisomerase 2

Epub 2004 Nov 8

once daily

ADX-47273 increased (9-fold) the response to threshold concentration of glutamate (50 nM) in fluorometric Ca(2+) assays (EC(50) = 170 nM) in human embryonic kidney 293 cells expressing rat mGlu5

ML792 Catalog No.:M7530-10 5-c]pyridin-6-yl]oxy]phenyl]-4-[2-(4-morpholinyl)ethoxy]-benzamideML 792 is a potent and selective inhibitor of SUMO (small ubiquitin like modifier) activating enzyme (SAE). ML 792 inhibits SAE SUMO1 and SAE SUMO2 in ATPinorganic pyrophosphate (PPi) exchange assays with IC50 of 3 nM and 11 nM, respectively. Product information CAS Number: 1644342 14 2 Molecular Weight: 551. 41 Formula: C21H23BrN6O5S Synonym: ML 792 ML 792 Chemical Name: ((1R,2S,4R) 4 ((5 (1 (3 bromobenzyl) 1H pyrazole 3 carbonyl)pyrimidin 4