MLN2238 - CAS# 1072833-77-2 Catalog No.:M6657-2 and ROCKII are all less

and ROCKII are all less than 10 nM and those for AKT1

Fiumelli H

InChi: InChI=1S/C21H16F4N4O2/c1-10-19(20(31)28-17-6-12-9-26-29-16(12)8-15(17)22)14(7-18(30)27-10)11-2-4-13(5-3-11)21(23

Molecular Weight: 576

IC50 values for the non-AGC kinases CHK2 and Aurora B are both greater than 800 nM

MLN2238 - CAS# 1072833-77-2 Catalog No.:M6657-2 and ROCKII are all lessMLN2238, CAS No. 1072833 77 2, is a potent proteasome inhibitor (PI) with potential antineoplastic activity. MNL2238 is also . the biologically active form of MLN9708. MLN2238 has an improved pharmacodynamic profile and antitumor activity compared with bortezomib in both OCI Ly10 and PHTX22L models. Although both MLN2238 and bortezomib prolonged overall survival, reduced splenomegaly, and attenuated IgG2a levels in the iMyc(C) Bcl X(L) GEM model, only