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P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid 02 μM for Hep 3B

P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid 02 μM for Hep 3B

Name: P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid 02 μM for Hep 3B
Brand: www.ab-travaux.com
SKU: 54414033520
Price: 45.00 USD
Availability: InStock
Rating: 4.0729 (28 reviews)

SKU: 54414033520

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P5091 - Ubiquitin-specific Protease 7 (USP7) Inhibitor. CAS# 882257-11-6 size:2 mg solid 02 μM for Hep 3BP5091 (P005091), CAS No. 882257 11 6, is a novel potent and selective inhibitor of ubiquitin specific protease 7 (USP7) with an IC50 ~4. 2 M. It does not inhibit other DUBs or other families of cysteine proteases tested (EC50 > 100 mM). It induces apoptosis in MM cells resistant to conventional and bortezomib therapies. Biochemical and genetic studies showed that blockade of HDM2 and p21 abrogated P5091 induced cytotoxicity. In animal tumor model

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Description

02 μM for Hep 3B

71(5):1573-83

Hedgehog signaling in development and cancer

and markedly inhibits the growth of EZH2 mutant DLBCL xenografts in mice

2-dichlorobenzene)

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