Afuresertib - CAS# 1047644-62-1 Catalog No.:M6803-10 Vesnarinone inhibits angiogenesis and tumorigenicity

Vesnarinone inhibits angiogenesis and tumorigenicity of human oral squamous cell carcinoma cells by suppressing the expression of vascular endothelial growth factor and interleukin-8

57(8):3205-12

43 μM) and causes altered cell cycle progression most clearly revealed under conditions of recovery from serum starvation

Biochem Biophys Res Commun

CAS Number: 105925-39-1

Afuresertib - CAS# 1047644-62-1 Catalog No.:M6803-10 Vesnarinone inhibits angiogenesis and tumorigenicityAfuresertib, CAS No. 1047644 62 1, also known as GSK 2110183 or GSK 2110183C, is an orally bioavailable inhibitor of the serine threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Afuresertib binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K Akt signaling pathway is