Tofogliflozin hydrate etyltransferase Inhibitor II Allosteric inhibition enhances the efficacy
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Tofogliflozin hydrate etyltransferase Inhibitor II Allosteric inhibition enhances the efficacyTofogliflozin, also known as CSG 452, is a potent and high selective SGLT2 inhibitor under development the treatment of diabetes mellitus. Tofogliflozin improves glycaemic control and lowers body weight in patients with type 2 diabetes mellitus. Tofogliflozin dose dependently suppressed glucose entry into tubular cells. High glucose exposure (30 mM) for 4 and 24 h significantly increased oxidative stress generation in tubular cells, which were
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