SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-2S OSI-027 shows robust antitumor activity

OSI-027 shows robust antitumor activity in several different human xenograft models representing various histologies

2 μM without affecting proteasome activity

Chronic treatment with novel GPR40 agonists improve whole-body glucose metabolism based on the glucose-dependent insulin secretion

GDC-0068 was used at 5-10 µM final concentration in vitro and in cellular assays

5(3):292-301

SR9009 - REV-ERB Agonist. CAS# 1379686-30-2 Catalog No.:M60236-2S OSI-027 shows robust antitumor activitySR9009, CAS No. 1379686 30 2, is a potent and specific synthetic REV ERB agonist that binds to REV ERB with an EC50 ~670 nM and REV ERB with EC50 ~800 nM. It also has good in vivo plasma brain exposure. The nuclear receptors REV ERB and REV ERB play an integral role in regulating the expression of core clock proteins, driving rhythms in activity and metabolism. Administration of SR9009 alters circadian behavior and the circadian pattern of core clock