IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 03 from the external membrane

03 from the external membrane surface

It significantly inhibits Ser910 and Ser935 phosphorylation of both wild-type LRRK2 and G2019S mutant at a concentration of 0

InChi: InChI=1S/C24H23N5O2/c1-15-12-18-17(22(25)30)8-5-9-21(18)29(15)24-27-20-10-11-31-14-19(20)23(28-24)26-13-16-6-3-2-4-7-16/h2-9

1186/scrt163

GTS-21 HCl

IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60116 03 from the external membraneIRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to