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TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid PubMed PMID: 8826855

TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid PubMed PMID: 8826855

Name: TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid PubMed PMID: 8826855
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TMP269 - Class IIa HDAC Inhibitor. CAS# 1314890-29-3 size:10mg solid PubMed PMID: 8826855TMP269, CAS No. 1314890 29 3, is a highly potent, selective and cell permeable class IIa HDAC inhibitor with IC50 of 126 nM, 80 nM, 36 nM and 19 nM for HDAC4, HDAC5, HDAC7 and HDAC9 respectively. It has very weak or no activity targeting the other HDACs (2 40 M). TMP269 has an unprecedented metal binding group, trifluoromethyloxadiazole (TFMO), which circumvents the selectivity and pharmacologic liabilities of hydroxamates. Crystallography revealed a

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PubMed PMID: 8826855

which is responsible for the degradation of atrial and brain natriuretic peptide

149(5):1060-1072

is a widely used

LY 2090314

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