Fenretinide - CAS# 65646-68-6 127 Divergent allosteric control of the

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

Alaseem AM

(2008) J Med Chem

5 day) potently and selectively inhibits IL-17 and IL-22 levels

inhibiting prolyl hydroxylation and increasing HIF-1α levels in cells (IC50 ~5

Fenretinide - CAS# 65646-68-6 127 Divergent allosteric control of theFenretinide, CAS No. 65646 68 6, is an orally active synthetic phenylretinamide analogue of retinol (vitamin A) with potential antineoplastic and chemopreventive activities. Fenretinide binds to and activates retinoic acid receptors (RARs), thereby inducing cell differentiation and apoptosis in some tumor cell types. This agent also inhibits tumor growth by modulating angiogenesis associated growth factors and their receptors and exhibits retinoid