TM 38837 Catalog No.:M7592-10 Molecular Weight: 608

Molecular Weight: 608

Lateral orbitofrontal cortical modulation on medial prefrontal cortex-amygdala pathway: Differential regulation of intra-amygdala GABAA and GABAB receptors

Combined inhibition of EGFR and CK2 augments the attenuation of PI3K-Akt-mTOR signaling and the killing of cancer cells

GSK429286A slightly inhibits RSK and p70S6K with IC50 of 0

5 μM) and displays antitumor activity in vivo

TM 38837 Catalog No.:M7592-10 Molecular Weight: 608Highly potent cannabinoid 1 receptor (CB1) inverse agonist (IC50 values are 8. 5 nM and 605 nM for inhibition of [3H] CP 55940 binding at CB1 and CB2 receptors, respectively). Displays 71 fold selectivity for CB1 receptors over CB2 receptors. Inhibits GTP binding to CB1 overexpressing cell membranes in vitro (EC50 = 18. 5 nM). Peripherally restricted. Promotes fear behaviors when given by intracerebrovascular (icv) injection in mice. Product