AGN 194310 I-3 The agent may enhance expression

The agent may enhance expression of the TGFβ-1 gene in a fashion analogous to that demonstrated for CsA

It up regulates PDX1 expression in both primary human islets and ductal cells

appears to have the potential to exert marked anxiolytic and antidepressant activity in humans

Formula: C21H21ClF2O4S

These data indicates that selective pharmacological inhibition of BCL-2 shows promise for the treatment of BCL-2–dependent hematological cancers

AGN 194310 I-3 The agent may enhance expressionAGN 194310, also known as VTP 194310, is a pan antagonist of retinoic acid receptors (RARs) with Kd values of 3nM, 2nM and 5nM for RAR , RAR and RAR, respectively. AGN 194310 has been reported to bind to RARs with equal and high Kd values of 3, 2 and 5nM for RAR , RAR and RAR, respectively, by in vitro binding experiments. In addition, AGN 194310 has been revealed to potently inhibit the colony formation by ITS+ grown cell lines with IC50 values of 16