CCT251545 - CAS# 1661839-45-7 050 Molecular Weight: 375

Molecular Weight: 375

335(3):715-27

increases the expression of p62 and Nrf2 and inactivates Keap1 in HN3-rslR cells

Epub 2011 Jun 15

Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death

CCT251545 - CAS# 1661839-45-7 050 Molecular Weight: 375CCT251545, CAS No. 1661839 45 7, is a potent small molecule inhibitor of WNT signaling with good oral pharmacokinetics. CCT251545 is a potent and selective chemical probe for the human Mediator complex associated protein kinases CDK8 and CDK19 with >100 fold selectivity over 291 other kinases. In contrast to type II inhibitors of CDK8 and CDK19, CCT251545 displays potent cell based activity. CCT251545 alters WNT pathway regulated gene expression and