Topotecan denosine The effect of KU-60019 on

The effect of KU-60019 on AKT S473 phosphorylation can be seen in glioma cell lines and normal fibroblasts but not in A-T (h-TERT) cells

Formula: C9H11IN2O5

(E)-N-(2-aminophenyl)-3-(1-((4-(1-methyl-1H-pyrazol-4-yl)phenyl)sulfonyl)-1H-pyrrol-3-yl)acrylamide 4-methylbenzenesulfonate

Behrendt HJ

PubMed PMID: 24758629

Topotecan denosine The effect of KU-60019 onTopocecan is a semisynthetic derivative of camptothecin with antineoplastic activity. During the S phase of the cell cycle, topotecan selectively stabilizes topoisomerase I DNA covalent complexes, inhibiting religation of topoisomerase I mediated single strand DNA breaks and producing potentially lethal double strand DNA breaks when complexes are encountered by the DNA replication machinery. Camptothecin is a cytotoxic quinoline based alkaloid