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31,32 A two year randomized clinical trial investigating the effect of a high dose of 100,000 International units (IU) (equivalent to 3,333 IU/day) versus the standard treatment 12,000 IU (equivalent to 400 IU/day) of oral vitamin D3 supplements for reducing risk of respiratory infections, was studied in 62 children and adolescents with SCD, aged 3-20 years

Finally, certain metabolites exclusive to the gut microbes can also function as endogenous hormones and signal through host-specific receptors to influence the metabolic processes

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But these were different trials, different populations, and different primary endpoints

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