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Leptin binds to the long-form leptin receptor (OB-Rb, LepR hereafter), which is highly expressed in the hypothalamus, and signals through JAK-STAT pathway ( 1, 15 )

Without that signal, the body is happy to catabolize muscle along with fat to meet its energy needs during a caloric deficit

List price: $1,069.08 per pen (GoodRx data, April 2026) With manufacturer coupon (if eligible): $25-550 depending on insurance Medicare/Medicaid: typically not covered for weight loss

On breastfeeding, the SmPC and the general public guidance differ, and that question is best discussed with your prescriber and midwife

Measuring the Dose and Getting the Injection Ready: Always follow the prescribed dose exactly

On March 8, 2024, the FDA approved Wegovy for cardiovascular risk reduction (for reducing the risk of heart attack, stroke, and cardiovascular death) in adult patients with cardiovascular diseases and obesity or overweight in combination with dietary modifications and increased physical activity