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Of significance, the decrease in GSH combined with diminished -glutamylcysteine ligase activity in these animals, renders Gclm/ fetal fibroblasts strikingly more sensitive to chemical oxidants (Yang et al., 2002)

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1 Introduction Oxidative stress is a potent regulator of the epigenetic landscape, influencing DNA methylation, histone modifications, and noncoding RNAs through both direct and indirect mechanisms (Chen and Shen, 2025)