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Several studies indicate that silymarin rmitigates the nephrotoxic effects of cisplatin without compromising its antitumor effect (Shahbazi 2012)

Our results showed that rats exposed to diazinon exhibited elevated levels of ALT and AST, indicating compromised liver function and hepatocellular damage

Methylmalonic acid concentration in serum not affected in hepatic disease

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However, since in that study radioabeled drugs was administered differentiation between the unchanged drug and its metabolites was impossible

The intricate balance of detoxification processes regulated by GSTs is pivotal in cellular homeostasis, whereby dysregulation in these mechanisms can have profound implications for human health