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This venom-derived molecule became exenatide (Byetta), the first GLP-1 agonist approved for the treatment of diabetes

Since many individuals with Hashimoto's experience weight gain and difficulty losing weight despite adequate thyroid hormone replacement, the appetite-suppressing properties of GLP-1 agonists may appear attractive

The most impressive impacts on metabolic profile in subjects receiving semaglutide or tirzepatide in these trials are on triglyceride values with up to 15% and 31% reductions respectively [33, 35, 48]

hypertension, type 2 DM, dyslipidemia) A meta-analysis of 22 trials involving over 17,000 patients determined that 50.2% and 17.5% of patients treated with GLP-1RAs (exenatide, semaglutide & liraglutide) experienced a weight loss of 5% and 10% compared to placebo, and that patients without type 2 diabetes achieved a significantly greater weight loss compared to those with diabetes (Vosoughi et al, 2022)