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Retatrutide is a novel weight management and diabetes treatment option

Nature 427 , 537541 (2004)

Research demonstrates that simultaneous GIP and GLP-1 activation produces a greater insulin response than either pathway alone

Additionally, GLP-1R signaling in -cells activates mTOR-dependent transcription of hypoxia-inducible factor 1 alpha (HIF-1), which upregulates glucose expression and promotes glucose metabolism [8, 9]