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10.1093/bib/bbab108 11 LardonJ.AbdellaouiR.BelletF.AsfariH.SouvignetJ.TexierN.et al (2015)

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EULAR recommendations for the non-pharmacological core management of hip and knee osteoarthritis: 2023 update

Weeks 14 0.25 mg Starter dose weekly Weeks 58 0.5 mg Increased weekly Weeks 916 1.0 mg Therapeutic dose Weeks 17+ 2.0 mg Maintenance dose Injection method Subcutaneous (under the skin) Frequency Once per week Provider check-ins Monthly dose adjustments Timeline 20 weeks to full dose What to expect Weight loss milestones and what patients typically experience at each phase

This medication enhances glucose-dependent insulin secretion from pancreatic beta cells, meaning it stimulates insulin release only when blood glucose levels are elevated, thereby reducing the risk of hypoglycaemia compared to some other diabetes medications