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J Parent Enteral Nutr 2007

These peptides should only be used in supervised research settings, and their use outside of such settings may carry unknown risks

Proposed mechanisms for hepatocyte necrosis include extreme hypertrophy leading to reduced sinusoidal blood circulation, hypoxia, and necrosis (Slauson and Cooper 2001) and/or metabolic activation forming more toxic active metabolites (Farber 1980)