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CB-839 is the most advanced GLS1 inhibitor currently in clinical practice and has been shown to effectively inhibit tumor proliferation (102)

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Due to aggregates being present in both high and low level formulations, antibody responses were observed in both but took either a persistent or transient form 30

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Moreover, up-expression of GSTA was suggested to protect liver cells against oxidative stress via an extracellular signal-regulated kinases (ERKs) and p38 kinase (p38K)-related pathway, as well as through the inhibition of H2O2-induced apoptosis to inhibit reactive oxygen species (ROS)- induced lipid peroxidation

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