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241 In -cells of patients with T2DM, the ability of GLP-1(936) to inhibit glucagon secretion is lost

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In a key clinical trial supporting the approval of teplizumab, participants taking the medication had a median time to a diagnosis of type 1 diabetes of 48 months compared to a median 24 months in those randomized to placebo

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One possible way to minimize the side-effects of the single drugs is to combine them to achieve synergistic effects, as reported recently with a combination of a DPP-IV inhibition, SSTR5 antagonism and GPR40 and TGR5 agonism, capable to raise circulatory active GLP-1(7-36) NH2 levels to more than 300-400 pM in mice (240)

Furthermore, a recent extensive cohort study involving over 33,000 GLP-1 RA users diagnosed with diabetes over a 9-year period indicated no significant increase in pancreatic cancer risk associated with GLP-1 RA use, as evidenced by an HR of 0.50 compared to basal insulin [60]