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Chronic Stress If you feel stressed, you are likely to have a high fasting cortisol level

By administering subcutaneous injections of D-Gal (at a dose of approximately 125300 mg/kg per day) for 610 weeks, a stable aging model can be established [41,42,43] Specifically concerning cardiac aging, D-Gal induces severe structural disorganization of the heart, substantial interstitial spaces between cells, and an increase in apoptotic myocardial cells [44]

Godtfredsen, N

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This modulation alters the expression of the key structural region of GSDMD-N in cell pyroptosis, thereby effectively improving MI-induced cardiac hypertrophy and fibrosis (Zhang et al., 2022)

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