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These must be weighed, especially in older patients or those with compromised renal or hepatic function

The conflicting data in some clinical studies may be explained by various factors: [1] most cohort studies lacked individual validation of fractures as primary outcomes, [2] the studies had short follow-up duration and [3] did not consider important risk factors for osteoporosis such as BMD (even though BMD is not a good method for diagnosing osteoporosis in T2DM), and [4] some studies included medications that affect fracture risk, such as corticosteroids or antidepressants

Sivanandy P, Leey TC, Xiang TC, Ling TC, Wey Han SA, Semilan SLA, et al

28 Multiple RCTs have studied the efficacy of intravenous and oral LOLA compared to placebo for treatment of HE (such as lactulose)

Blood tests may be conducted to rule out other forms of arthritis, such as rheumatoid arthritis