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Ben Lynch: Yeah, that's my understanding, too

Cell death regulation by MAMs: from molecular mechanisms to therapeutic implications in cardiovascular diseases

Franzoni, E

In mouse models of insulin resistance, it significantly inhibits NNMT activity in liver and muscle, reduces NAM methylation, increases intracellular NAD+, activates the SIRT1 pathway, promotes phosphorylation of insulin receptor substrate 1 (IRS1), enhances insulin signaling, improves insulin sensitivity, and increases glucose uptake and utilization

Although its pathogenesis may vary depending on geography, genetic factors, and environmental influences, hypothyroidism is often considered a chronic and ongoing health problem (Centanni et al., 2017