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Diabetologia 54:26492659

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Nutrient-induced gut peptides can act in a paracrine fashion by activating vagal neurons that innervate tissue near the intestinal epithelium and signal to the brain or in an endocrine fashion targeting the brain and other peripheral organs involved in maintaining metabolic homeostasis 17

In addition, postprandial glycemia is an independent cardiovascular risk factor and predicts all-cause mortality (76), and accordingly, represents a specific target for the treatment of type 2 diabetes