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Many of the human observational studies including the cohort data reporting lower mortality and improved melatonin rhythms in elderly subjects used epithalamin, not synthetic epitalon

Thus, interfering with proIGF-1Ea glycosylation provides a means to regulate IGF-1 production

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These gene expression data are available through the Gene Expression Omnibus (GEO) under the accession GSE27597

However, this isnt an unavoidable outcome

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