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TRIUMPH-3 (NCT05882045): 80-week weight management trial in adults with obesity/overweight and established cardiovascular disease

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GLP-1 receptors in the ventral tegmental area sit on GABAergic neurons rather than on dopamine neurons, so the agonist raises inhibitory tone onto dopamine cells rather than acting on them directly

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"So this is Wegovy, you take it four times a month," says the 45-year-old