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119 Beyond canonical incretin pathways, nextgeneration coagonists targeting GLP1, GIP, and glucagon receptors (e.g., retatrutide) optimize systemic lipid metabolism and improve peripheral insulin sensitivity

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This leads to significant weight loss, helping individuals reach and maintain their target weight, which is crucial for overall health and well-being

Those using a 1.0 mg dose experienced a drop of 1.9 points at the same time

Cells were lysed using RIPA buffer (50 mM Tris pH 7.5, 150 mM NaCl, 1% NP-40, 0.5% sodium deoxycholate, and 0.1% sodium dodecyl sulfate, 2 mM DTT, 2 mM sodium orthovanadate, 1 protease inhibitor cocktail [Roche])

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