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Combination therapy with oral ALA, betamethasone injection and NB-UVB has also been shown to be beneficial in non-segmental progressive vitiligo [126]

N-(7-(dimethylamino)-3h-phenothiazin-3-ylidene)-n-methylmethanaminiumchloride 190

It has been proposed that all children and adults with AIH and cholestatic clinical or biochemical profiles (pruritus and/or elevated gamma-glutamyl transferase), non-response to first-line treatments, and those with concurrent ulcerative colitis, should be evaluated for ASC/overlap [29, 42, 183,184,185]

In addition to earlier theories such as metaplasia (12) and the widely accepted retrograde tubal endometrial reflux theory of Sampson (13), other immune-mediated pathways including chronic inflammation, apoptosis, angiogenesis and endothelial dysfunction have also been implicated (14,15)

Glutathione is a natural antioxidant made from glycine, glutamic acid and cysteine which helps in maintaining a healthy immune system

Cycle 48 weeks on, then 2 weeks off to maintain receptor sensitivity