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Other strategies would involve using inhibitors that target Nrf2 such as, the quassinoid brusatol 79 , the alkaloid trigonelline 80 and the flavonoid luteolin 81 , all of which showed efficacy in inhibiting Nrf2 activity and prevented chemo-resistance

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In particular, SKN increased nitric oxide production through upregulation of endothelial nitric oxide synthase and proliferator-activated receptor alpha expression, while simultaneously decreasing iNOS, COX-2, and other oxidative markers