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GLP-1 also has important anti-inflammatory effects

Thyroid 21 (9), 957963

Lancet Diabetes Endocrinol 4(3):221232

Neuroprotective Studies MC1R activation influences AMPK, SIRT1, and PGC-1 pathways that regulate mitochondrial metabolism

Interaction with insulin, glucagon and epinephrine

Some practitioners theorize that establishing robust GLP-1-supporting gut bacteria before discontinuing medication could provide a partial buffer against rebound effects, maintaining some degree of natural GLP-1 production even after the pharmaceutical support is removed