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In an international trial involving over 500 patients with impaired glucose tolerance, treatment with acarbose significantly improved glucose tolerance, and reduced the risk of progression to diabetes by 25% over 3.3 years (Chiasson 2002)

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Additionally, the researchers found that GEP44 exhibits biased agonism at the Y2-R, as documented by its inability to induce Y2-R-mediated increases in intracellular Ca2+ or ERK1/2 phosphorylation

Specifically, propionate promotes the differentiation of regulatory T cells (Tregs) and suppresses the production of pro-inflammatory cytokines, thereby reducing intestinal inflammation and inhibiting CRC development (Wang et al., 2019)