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After propensity score matching the GLP-1 cohort (n=45,704) included 35,753 (78.2%) women and 7,852 (17.2%) men with a mean age of 61.1, while the OWLD cohort (n=45,704) included 35,732 (78.2%) women and 7,815 (17.1%) men with a mean age of 61.0

Some individuals, particularly those who experienced significant GI distress on previous GLP-1 medications, benefit from even slower titrationpotentially extending the 2 mg phase to 6-8 weeks before advancing