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4 A case for targeting IGF-1R was based on several observations

Source Data Extended Data Fig

Carnitine reduces fasting ketogenesis in patients with disorders of propionate metabolism

Because the components are co-lyophilised, one reconstitution step puts all three into solution at a fixed ratio, and they cannot subsequently be separated or independently varied

By scavenging free radicals, glutathione protects the mitochondria of the cell

While LBM loss appears to be less pronounced than FBM loss in many studies, the clinical significance of even modest reductions in skeletal muscle remains uncertain, particularly in older adults or individuals at risk of sarcopenia