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The clinical payoff of this dual mechanism was established in the SURMOUNT-1 trial, a phase 3 randomized, double-blind, placebo-controlled study of 2,539 adults with obesity or overweight without diabetes

* Correspondence: Anas Islam, [email protected] ORCID: Anas Islam, orcid.org/0000-0003-2094-9435 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers