Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Required for proper 27S pre-rRNA

Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly

A second copy of this gene within the centromeric copy of the duplication has been described in the literature

Eight alternatively spliced transcript variants have been described

it is now thought to be a non-opioid receptor

Translocations between MLF1 and nucleophosmin have been associated with myelodysplastic syndrome and acute myeloid leukemia

Dok-2 Polyclonal Antibody, 50ul[BT-AP02698] Hybridoma Antibody Sequencing Required for proper 27S pre-rRNAThe protein encoded by DOK2 (docking protein 2)is constitutively tyrosine phosphorylated in hematopoietic progenitors isolated from chronic myelogenous leukemia (CML) patients in the chronic phase. It may be a critical substrate for p210 (bcr abl), a chimeric protein whose presence is associated with CML. This encoded protein binds p120 (RasGAP) from CML cells.