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The novel glutamine antagonist prodrug JHU395 has antitumor activity in malignant peripheral nerve sheath tumor

2 Methods 2.1 Animals and procedures The animal experimental procedures were approved by the Animal Care and Use Committee of Oujiang Laboratory (SYXK2023-0047, OJLAB22121609), and were carried out in strict accordance with the National Institutes of Health Guidelines for the Use of Laboratory Animals

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(2021) found that SFN-induced cell death was mediated via ferroptosis and inhibition of SLC7A11 mRNA and protein expression levels in SCLC cells, leading to reduced GSH and increased lipid ROS levels

Overexpressed xCT was responsible for the reduction in eumelanin formation in melanocytes and increased production of pheomelanin in the sheep wool, where brown/yellow patches were observed [91]

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