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This model provided no evidence to support an indirect (mediating) effect of excess IL-6 on Phase-associated dACC glutamate (Fig

Future research needs to focus on pharmacodynamic optimization and clinical transformation to realize the potential value of erianin in the treatment of diabetic complications

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Hyperglycemia, AGEs, mitochondrial oxidative stress and ultrafiltration cytokines act on renal tubular cells and trigger multiple cellular pathways such as PKC-, -, and -, NF-B, P38 and ERK1/2 pathways, further exacerbating renal tubular cell hypertrophy, apoptosis, and accumulation of tubulointerstitial inflammatory factors (3)